2022 PROZINC® (protamine zinc recombinant human insulin) Feline Brochure

YOU CAN

DO THIS.

INFORMATION AND TIPS

TO HELP YOU MANAGE YOUR

CAT’S DIABETES.

With the right care

and treatment, your

diabetic cat can get

back on track! Read

on to learn what you

should do to help.

SOME SIGNS OF

FELINE DIABETES ARE:

Increased thirst: High levels of glucose in

the urine can cause dehydration, resulting in

excessive thirst in your cat.

Increased urination: Excessive thirst and

high levels of glucose in the urine may result

in more frequent urination or an increase in

urine volume.

Increased appetite: Imbalanced blood

glucose and inability of glucose to enter cells

to support normal metabolism can cause your

cat to feel hungry more often.

Weight loss: A diabetic cat’s body will break

down stored fats and proteins to replace

glucose as an energy source, resulting in

weight loss despite increased appetite.

THE GOOD NEWS IS THAT

DIABETES IS MANAGEABLE.

WHY IS INSULIN IMPORTANT?

WHAT IS DIABETES? YOU’RE NOT ALONE.

If your cat was just diagnosed with diabetes

or if your cat’s diabetes has been difficult to

control, providing the right care may seem

overwhelming or frustrating. If you feel this

way, you are not alone. As many as half a

million cats in the US are diagnosed with

diabetes, and this can be a challenging time

for many of their owners.

1,2

Feline diabetes mellitus occurs when a

cat’s body doesn’t produce enough insulin

or doesn’t respond effectively to insulin.

Insulin works as the “key” that lets your cat’s

cells utilize glucose for energy. When diabetes

disrupts this normal process, it results in a

shortage of glucose within the cells and an

excess of glucose in the bloodstream. It is this

imbalance of glucose that contributes to the

signs we see in diabetic cats.

Your Cat Has Been Diagnosed

WITH DIABETES

TRY TO KEEP A REGULAR SCHEDULE

FOR YOUR CAT, ESPECIALLY WHEN IT

COMES TO THESE ACTIVITIES:

INSULIN THERAPY

For cats with diabetes, lifestyle changes

such as an activity plan, a special diet,

and regular visits to the vet can help. However,

most cats with diabetes will also need

insulin injections.

DIET

What your cat eats is very important.

Discuss your cat’s diet with your veterinarian to

determine what kind of food is best for your cat.

When

your cat eats is also important, so be sure

to keep your cat’s feedings as close to the same

time each day as you can.

ACTIVITY AND PLAY

For a cat with diabetes, exercise can

make a difference in maintaining a

healthy blood glucose level. Like feeding,

activity should happen consistently,

every day.

VETERINARY VISITS

Be sure to discuss your cat’s diabetes

during regular veterinary appointments,

which may include blood glucose monitoring. This

will help your veterinarian determine whether your

cat is responding as expected or if an adjustment

in the insulin regimen is needed.

ROUTINE TIP

Establishing and maintaining

new routines may require the

cooperation of others in your

household. Get them involved

and share the responsibility

of providing the care that

your cat needs.

For a cat with diabetes, keeping a consistent

routine goes a long way in helping your cat’s

body maintain steady glucose levels.

Proper care is critical to keeping

your diabetic cat healthy.

Managing Your Cat’s

DIABETES

PROZINC

(protamine zinc recombinant human insulin)

is approved by the FDA for use in cats and will

help you care for your cat easily and effectively.

PROZINC insulin injections should be given

with or preferably just after a meal.

PROZINC

is extensively studied.

PROZINC was proven safe and effective in

the largest clinical feline insulin trial to date,

so you can feel confident giving PROZINC

to your cat to help manage diabetes.

Healthy cats are able to regulate their blood glucose levels

with the help of insulin that’s produced in the body.

Cats with diabetes have a harder time maintaining those

levels throughout the day, due to an ineffective response

to insulin or an insulin deficiency. That’s where PROZINC

comes in.

With 2 daily doses, you can provide your diabetic cat the

help it needs to regulate its blood glucose and relieve

associated clinical signs.

With the proven safety profile

of PROZINC, it’s the feline insulin treatment you can feel

confident about.

HOW PROZINC

HELPS

GIVING YOUR CAT PROZINC.

Give injections at the same time every day.

Keep a consistent feeding schedule to

help ensure proper treatment.

Your Veterinarian Prescribed

PROZINC

WARNING – USER SAFETY: For use in dogs and cats only. Keep out

of the reach of children. Avoid contact with eyes. In case of contact,

immediately ﬂush eyes with running water for at least 15 minutes.

Accidental injection may cause hypoglycemia. In case of accidental

injection, seek medical attention immediately. Exposure to product may

induce a local or systemic allergic reaction in sensitized individuals.

Remember to roll the vial rather than

shake it.

Visit our video library for step-by-step

dosing instructions and more.

https://prozinc.us/cat-owners/prozinc-video-library

Be sure to give your cat the number of units prescribed

by your veterinarian. Do not try to adjust your cat’s

dosage without your veterinarian’s supervision.

Reference:

Nelson RW, Henley K, Cole C, et al. Field safety and efficacy

of protamine zinc recombinant human insulin for treatment

of diabetes mellitus in cats. J Vet Intern Med. 2009;23:787-802.

With patience and diligent care,

PROZINC

(protamine zinc recombinant

human insulin) can help bring your cat’s

clinical signs of diabetes, and high blood

glucose, under control so they can live a

happy and virtually normal life.

IN A CLINICAL FIELD TRIAL,

MOST CATS TREATED WITH

PROZINC

SHOWED IMPROVEMENT

WITHIN 45 DAYS

In fact,

ABOUT HALF

of the cats in the

studies showed

IMPROVEMENT IN

JUST 7 DAYS

3,4

REMISSION

REGULATING YOUR CAT’S

BLOOD GLUCOSE

It may take a month or longer to regulate your cat’s

blood glucose. But once it is regulated, you will notice

an improvement in the signs of diabetes (increased

thirst, urination, and appetite). When these signs

decrease or disappear, you’ll know your cat’s blood

glucose is stabilizing and your cat is likely to feel better.

Even if the signs of diabetes are gone, it is important to

have routine checkups so your veterinarian can assess

your cat’s response to insulin therapy.

While there is no actual cure, it is possible for your

cat’s diabetes to go into remission. This happens when

the concentration of glucose in your cat’s blood stays

at a normal level for at least 4 weeks without insulin

treatment.

It is important to remember that even if

your cat’s diabetes is in remission, and they have

been taken off PROZINC, their ability to secrete

insulin is still abnormal and dietary modifications

should be continued.

IMPORTANT SAFETY INFORMATION: PROZINC

(protamine zinc recombinant

human insulin) is for use in dogs and cats only. Keep out of the reach of children.

As with all insulin products, careful patient monitoring for hypoglycemia and

hyperglycemia is essential to attain and maintain adequate glycemic control

and to prevent associated complications.

Overdose can result in profound hypoglycemia and death. The most common

adverse reactions were lethargy, anorexia, hypoglycemia, vomiting, seizures,

diarrhea, and ataxia. Many of the adverse reactions, such as lethargy,

seizures, and ataxia, are associated with hypoglycemia. Glucocorticoid and

progestogen use should be avoided.

The safety and effectiveness of PROZINC in kittens, or breeding, pregnant,

and lactating animals has not been evaluated. PROZINC is contraindicated

during episodes of hypoglycemia and in animals sensitive to protamine zinc

recombinant human insulin or any other ingredients in PROZINC.

For more information, please see full prescribing

information located at the end of brochure.

76% showed improvement

in excessive thirst.

74% showed improvement

in excessive urination.

What To Expect With

PROZINC

FOR MORE DIABETES

RESOURCES, SCAN THE

QR CODE BELOW.

REGULAR VISITS TO YOUR

VETERINARIAN ARE IMPORTANT

to monitor disease progress and to make

dosing adjustments as necessary.

Even after your cat’s glucose levels

are stabilized on PROZINC,

Hypoglycemia (low blood glucose) is a dangerous and

potentially life-threatening condition that can occur if

your cat has too much insulin, too little food, or much

more activity than usual.

WAYS TO HELP YOUR CAT

AVOID HYPOGLYCEMIA.

First, make sure to give your cat the correct dose of

PROZINC

(protamine zinc recombinant human insulin)

on a consistent schedule.

• Maintain a regular feeding schedule

• Provide the exact amount of food

recommended by your veterinarian

• Do not give your cat any prescription or

over-the-counter medications without your

veterinarian’s supervision—this includes

vitamins and supplements

Hypoglycemia requires your immediate

attention and can be fatal for your

cat without prompt treatment, so it’s

important to recognize the signs:

IF YOU SUSPECT YOUR CAT HAS

LOW BLOOD GLUCOSE, FOLLOW

THESE STEPS:

If your cat isn’t conscious, rub a teaspoon

of corn syrup or honey on your cat’s gums and take

them to an emergency provider immediately.

If your cat is having a seizure, take your

cat to the veterinarian immediately.

If your cat is conscious, and is able to swallow,

hand-feed corn syrup or honey until they are alert

enough to eat normal food.

As soon as your cat is alert enough to eat,

feed the next scheduled meal instead of waiting

for mealtime, and call your veterinarian for advice.

Remember that hypoglycemia is a dangerous

condition that can’t wait. It is a medical emergency

that requires you to take action immediately.

What to do in an emergency.

• Extreme lethargy

• Depression

• Lack of Coordination

• Loss of Consciousness

• Unusual behavior

• Muscle twitching

• Seizure

• Coma

What Is

HYPOGLYCEMIA?

https://prozinc.us/cat-owners

40 IU/mL

Caution: Federal law restricts this drug to use by or on the order of a

licensed veterinarian.

Description: PROZINC® is a sterile aqueous protamine zinc suspension of

recombinant human insulin.

Each mL contains:

recombinant human insulin 40 International Units (IU)

protamine sulfate 0.466 mg

zinc oxide 0.088 mg

glycerin 16.00 mg

dibasic sodium phosphate, heptahydrate 3.78 mg

phenol (added as preservative) 2.50 mg

hydrochloric acid 1.63 mg

water for injection (maximum) 1005 mg

pH is adjusted with hydrochloric acid and/or sodium hydroxide.

Indication: PROZINC (protamine zinc recombinant human insulin) is

indicated for the reduction of hyperglycemia and hyperglycemia-associated

clinical signs in cats with diabetes mellitus.

Dosage and Administration: USE OF A SYRINGE OTHER THAN A U-40

SYRINGE WILL RESULT IN INCORRECT DOSING.

FOR SUBCUTANEOUS INJECTION ONLY.

DO NOT SHAKE OR AGITATE THE VIAL.

PROZINC should be mixed by gently rolling the vial prior to withdrawing

each dose from the vial. Once mixed, PROZINC suspension has a white,

cloudy appearance. Clumps or visible white particles can form in insulin

suspensions: do not use the product if clumps or visible white particles

persist after gently rolling the vial.

Using a U-40 insulin syringe, the injection should be administered

subcutaneously on the back of the neck or on the side of the cat.

Always provide the Client Information Sheet with each prescription.

The initial recommended PROZINC dose is 0.1 – 0.3 IU insulin/pound of

body weight (0.2 – 0.7 IU/kg) every 12 hours. The dose should be given

concurrently with or right after a meal. The veterinarian should re-evaluate

the cat at appropriate intervals and adjust the dose based on both clinical

signs and glucose nadirs until adequate glycemic control has been attained.

In the effectiveness ﬁeld study, glycemic control was considered adequate

if the glucose nadir from a 9-hour blood glucose curve was between 80 and

150 mg/dL and clinical signs of hyperglycemia such as polyuria, polydipsia,

and weight loss were improved.

Further adjustments in the dosage may be necessary with changes in the

cat’s diet, body weight, or concomitant medication, or if the cat develops

concurrent infection, inﬂammation, neoplasia, or an additional endocrine or

other medical disorder.

Contraindications: PROZINC is contraindicated in cats sensitive to

protamine zinc recombinant human insulin or any other ingredients in

PROZINC. PROZINC is contraindicated during episodes of hypoglycemia.

Warnings: User Safety: For use in cats and dogs only. Keep out of the reach

of children. Avoid contact with eyes. In case of contact, immediately ﬂush

eyes with running water for at least 15 minutes. Accidental injection may

cause hypoglycemia. In case of accidental injection, seek medical attention

immediately. Exposure to product may induce a local or systemic allergic

reaction in sensitized individuals.

Package Insert for Cats

ProZinc®

(protamine zinc recombinant human insulin)

Animal Safety: Owners should be advised to observe for signs of

hypoglycemia (see Client Information Sheet). Use of this product, even

at established doses, has been associated with hypoglycemia. A cat with

signs of hypoglycemia should be treated immediately. Glucose should be

given orally or intravenously as dictated by clinical signs. Insulin should be

temporarily withheld and, if indicated, the dosage adjusted.

Any change in insulin should be made cautiously and only under a

veterinarian’s supervision. Changes in insulin strength, manufacturer,

type, species (human, animal) or method of manufacture (rDNA versus

animal-source insulin) may result in the need for a change in dosage.

Appropriate diagnostic tests should be performed to rule out other

endocrinopathies in diabetic cats that are difﬁcult to regulate.

Precautions: Cats presenting with severe ketoacidosis, anorexia, lethargy,

and/or vomiting should be stabilized with short-acting insulin and

appropriate supportive therapy until their condition is stabilized. As with

all insulin products, careful patient monitoring for hypoglycemia and

hyperglycemia is essential to attain and maintain adequate glycemic control

and to prevent associated complications. Overdose can result in profound

hypoglycemia and death.

Glucocorticoids, progestogens, and certain endocrinopathies can have an

antagonistic effect on insulin activity. Glucocorticoid and progestogen use

should be avoided.

The safety and effectiveness of PROZINC in breeding, pregnant, and lactating

cats has not been evaluated.

The safety and effectiveness of PROZINC in kittens has not been evaluated.

Adverse Reactions: Effectiveness Field Study

In a 45-day effectiveness ﬁeld study, 176 cats received PROZINC.

Hypoglycemia (deﬁned as a blood glucose value of < 50 mg/dL) occurred

in 71 of the cats at various times throughout the study. Clinical signs of

hypoglycemia were generally mild in nature (described as lethargic, sluggish,

weak, trembling, uncoordinated, groggy, glassy-eyed or dazed). In 17 cases,

the veterinarian provided oral glucose supplementation or food as treatment.

Most cases were not associated with clinical signs and received no

treatment. One cat had a serious hypoglycemic event associated with stupor,

lateral recumbency, hypothermia and seizures.

All cases of hypoglycemia resolved with appropriate therapy and if needed, a

dose reduction.

Three cats had injection site reactions which were described as either small,

punctate, red lesions; lesions on neck; or palpable subcutaneous thickening.

All injection site reactions resolved without cessation of therapy.

Four cats developed diabetic neuropathy during the study as evidenced by

plantigrade stance. Three cats entered the study with plantigrade stance,

one of which resolved by Day 45. Four cats were diagnosed with diabetic

ketoacidosis during the study. Two were euthanized due to poor response to

treatment. Five other cats were euthanized during the study, one of which

had hypoglycemia. Four cats had received PROZINC for less than a week and

were euthanized due to worsening concurrent medical conditions.

The following additional clinical observations or diagnoses were reported in

cats during the effectiveness ﬁeld study: vomiting, lethargy, diarrhea, cystitis/

hematuria, upper respiratory infection, dry coat, hair loss, ocular discharge,

abnormal vocalization, black stool, and rapid breathing.

Extended Use Field Study

Cats that completed the effectiveness study were enrolled into an extended

use ﬁeld study. In this study, 145 cats received PROZINC for up to an

additional 136 days. Adverse reactions were similar to those reported

during the 45-day effectiveness study and are listed in order of decreasing

frequency: vomiting, hypoglycemia, anorexia/poor appetite, diarrhea,

lethargy, cystitis/hematuria, and weakness. Twenty cats had signs

consistent with hypoglycemia described as: sluggish, lethargic, unsteady,

wobbly, seizures, trembling, or dazed. Most of these were treated by the

owner or veterinarian with oral glucose supplementation or food; others

received intravenous glucose. One cat had a serious hypoglycemic event

associated with seizures and blindness. The cat fully recovered after

supportive therapy and ﬁnished the study. All cases of hypoglycemia

resolved with appropriate therapy and if needed, a dose reduction.

Fourteen cats died or were euthanized during the extended use study.

In two cases, continued use of insulin despite anorexia and signs of

hypoglycemia contributed to the deaths. In one case, the owner decided

not to continue therapy after a presumed episode of hypoglycemia.

The rest were due to concurrent medical conditions or worsening of the

diabetes mellitus.

To report suspected adverse drug events, for technical assistance or to

obtain a copy of the Safety Data Sheet (SDS), contact Boehringer

Ingelheim at 1-888-637-4251.

For additional information about adverse drug experience reporting

for animal drugs, contact FDA at 1-888-FDA-VETS or online at

http://www.fda.gov/reportanimalae.

Information for Cat Owners: Please refer to the Client Information Sheet

for Cats for more information about PROZINC. PROZINC, like other

insulin products, is not free from adverse reactions. Owners should

be advised of the potential for adverse reactions and be informed

of the associated clinical signs. Potential adverse reactions include:

hypoglycemia, insulin antagonism/resistance, rapid insulin metabolism,

insulin-induced hyperglycemia (Somogyi Effect), and local or systemic

reactions. The most common adverse reaction observed is hypoglycemia.

Signs may include: weakness, depression, behavioral changes, muscle

twitching, and anxiety. In severe cases of hypoglycemia, seizures and

coma can occur. Hypoglycemia can be fatal if an affected cat does

not receive prompt treatment. Appropriate veterinary monitoring of

blood glucose, adjustment of insulin dose and regimen as needed, and

stabilization of diet and activity help minimize the risk of hypoglycemic

episodes. The attending veterinarian should evaluate other adverse

reactions on a case-by-case basis to determine if an adjustment in

therapy is appropriate, or if alternative therapy should be considered.

Effectiveness: A total of 187 client-owned cats were enrolled in a 45-day

ﬁeld study, with 176 receiving PROZINC. One hundred and ﬁfty-one cats

were included in the effectiveness analysis. The patients included various

purebred and mixed breed cats ranging in age from 3 to 19 years and in

weight from 4.6 to 20.8 pounds. Of the cats included in the effectiveness

analysis, 101 were castrated males, 49 were spayed females, and 1 was an

intact female.

Cats were started on PROZINC at a dose of 0.1-0.3 IU/lb (0.2-0.7 IU/kg)

twice daily. Cats were evaluated at 7, 14, 30, and 45 days after initiation of

therapy and the dose was adjusted based on clinical signs and results of

9-hour blood glucose curves on Days 7, 14, and 30.

Effectiveness was based on successful control of diabetes which was

deﬁned as improvement in at least one blood glucose variable (glucose

curve mean, nadir, or fructosamine) and at least one clinical sign

(polyuria, polydipsia, or body weight). Based on this deﬁnition, 115 of 151

cases (76.2%) were considered successful. Blood glucose curve means

decreased from 415.3 mg/dL on Day 0 to 203.2 mg/dL by Day 45 and

the mean blood glucose nadir decreased from 407.9 mg/dL on Day 0 to

142.4 mg/dL on Day 45. Mean fructosamine values decreased from 505.9

μmol/L on Day 0 to 380.7 μmol/L on Day 45.

Cats that completed the effectiveness study were enrolled in an extended use

ﬁeld study. The mean fructosamine value was 342.0 μmol/L after a total of

181 days of PROZINC therapy.

How Supplied: PROZINC is supplied as a sterile injectable suspension in

10 mL and 20 mL multi-dose vials. Each mL of PROZINC contains 40 IU

recombinant human insulin.

Storage Conditions: Store in an upright position under refrigeration at 36-

46°F (2-8°C). Do not freeze. Protect from light. Use the 10 mL vial within 60

days of ﬁrst puncture. Use the 20 mL vial within 80 days of ﬁrst puncture.

Approved by FDA under NADA # 141-297

Marketed by:

Boehringer Ingelheim Animal Health USA Inc.

Duluth, GA 30096

PROZINC® is a registered trademark of Boehringer Ingelheim Animal Health

USA Inc.

US-PET-0697-2021

Revised 08/2019

449986-01

• All medications that you are giving your cat or plan to give your cat,

including those you can get without a prescription.

• If your cat is pregnant, nursing, or if you plan to breed your cat.

What are the possible side effects that may occur in my cat during

PROZINC therapy?

PROZINC, like other drugs, may cause side effects. Serious side

effects can occur with or without warning. Please contact your

veterinarian immediately if you think your cat has a medical problem

or side effect from PROZINC therapy. The most common insulin-

related side effect is low blood sugar (hypoglycemia). Signs of low

blood sugar (hypoglycemia) can occur suddenly and may include:

• Weakness • Staggering gait

• Muscle twitching • Coma

• Depression, lethargy, sluggishness • Behavioral changes

• Seizures, convulsions • Death

What actions do I take if my cat shows signs of low blood

sugar (hypoglycemia)?

• If your cat is unconscious or having a seizure, this is a medical

emergency. Take your cat to the veterinarian immediately.

• If your cat is conscious, rub approximately 1 tablespoon of corn

syrup or honey on your cat’s gums. When it is able to swallow, give

corn syrup or honey by mouth until your cat is alert enough to eat.

Feed the usual meal and contact your veterinarian.

When should my cat not be given PROZINC?

Do not give your cat its prescribed dose of PROZINC if it:

• Is experiencing an episode of low blood sugar (hypoglycemia).

Common causes for low blood sugar include excessive doses of

insulin, failure to eat, strenuous exercise, changes in the body’s

need for insulin, diabetes-inducing disease or drug effects.

• Is not eating or is vomiting.

• Is sensitive to protamine zinc recombinant human insulin or any

other ingredients in PROZINC.

• Do not give your cat its prescribed dose of PROZINC if you see

clumps or visible white particles in the vial after gently rolling.

How should I give PROZINC to my cat?

PROZINC should be given with or right after a meal.

Give PROZINC with U-40 syringes only. Use of a syringe other than

a U-40 syringe will result in incorrect dosing. Gently roll the vial until

the PROZINC has a uniformly cloudy, white appearance. If there are

clumps or visible white particles in the vial after gently rolling, do

not use the PROZINC and call your veterinarian. PROZINC should be

given according to your veterinarian’s instructions. Your veterinarian

will tell you what amount of PROZINC is right for your cat and

instruct you on techniques for administration.

Can PROZINC be given with other medications?

PROZINC can be given with other medications, but the dose may

need to be adjusted due to the medication resulting in either

increased or decreased insulin requirements. Tell your veterinarian

about all medications you have given your cat in the past, and any

medications that you are planning to give with PROZINC. This

should include medications that you can get for your cat without a

prescription. Your veterinarian may want to ensure that all of your

cat’s medications can be given together.

40 IU/mL

This summary contains important information about PROZINC.

You should read this information before you start giving your cat

PROZINC and review it each time the prescription is reﬁlled. This

sheet is provided only as a summary and does not take the place of

instructions from your veterinarian. Talk to your veterinarian if you

do not understand any of this information or if you want to know

more about PROZINC.

What is PROZINC?

PROZINC is an aqueous protamine zinc suspension of

recombinant human insulin that is used to reduce high blood

sugar (hyperglycemia) in cats with diabetes mellitus. A veterinarian

must prescribe PROZINC for your cat. PROZINC should be given

to cats only. Keep out of reach of children. Seek medical attention

immediately if you accidentally inject yourself with PROZINC.

What is diabetes mellitus?

Diabetes mellitus occurs when a cat has insufﬁcient levels of, or an

abnormal response to, insulin. The low insulin levels may result in

high blood sugar (hyperglycemia) that could produce the following

changes in your cat:

• Increased thirst

• Increased appetite

• High levels of sugar (glucose) in the urine (glucosuria)

• Increased urination

• Weight loss

• Weakness in the back legs

What kind of results can I expect when my cat is on PROZINC for

diabetes mellitus?

Although PROZINC is not a cure for diabetes mellitus, it can help

reduce the levels of sugar (glucose) in the blood, which can help

alleviate the clinical signs.

What should I discuss with my veterinarian before giving PROZINC?

Talk to your veterinarian about:

• The signs of diabetes mellitus you have observed in your cat

(for example, increased thirst and urination).

• The importance of proper PROZINC storage, handling, and

administration techniques (for example, how to gently roll the vial

prior to each use, the proper appearance of product after gently

rolling, how to ﬁll the U-40 syringe with the proper amount of

insulin, and where and how to inject the insulin).

• The importance of maintaining your cat under the same conditions

for diet, exercise, environment, etc.

• The importance of follow-up visits for testing to determine if dose

adjustments of PROZINC are necessary.

Tell your veterinarian about:

• Any side effects your cat has had when receiving other

insulin products.

• Any medical problems or allergies that your cat has now or has

had in the past.

Client Information Sheet for Cats

ProZinc®

(protamine zinc recombinant human insulin)

What should I do if I inject more than the prescribed amount

of PROZINC?

Contact your veterinarian immediately and, if your veterinarian is not

available, seek other veterinary advice at once.

What should I do if my cat receives less than the prescribed dose, or

I miss an injection?

• Contact your veterinarian as soon as possible for advice on your

cat’s next dose.

• If you cannot reach your veterinarian and your cat is eating and

acting normally, give your cat the usual dose at the next regularly

scheduled injection time.

How should I store PROZINC?

PROZINC should be stored in an upright position under refrigeration

at 36-46°F (2-8°C). Do not freeze. Protect from light. Use the 10 mL

vial within 60 days of ﬁrst puncture. Use the 20 mL vial within 80

days of ﬁrst puncture.

What else should I know about PROZINC?

This sheet provides a summary of information about PROZINC. If

you have any questions or concerns about the product or diabetes

mellitus, talk to your veterinarian.

As with all prescribed medications, PROZINC should only be given

to the cat for which it is prescribed and for the condition for which it

was prescribed.

It is important to periodically discuss your cat’s response to

PROZINC at regular checkups that may include blood glucose

monitoring. Your veterinarian will best determine if your cat is

responding as expected and should continue receiving PROZINC.

Approved by FDA under NADA # 141-297

PROZINC® is a registered trademark of Boehringer Ingelheim Animal

Revised 08/2019

PROZINC

is a registered trademark of

Boehringer Ingelheim Animal Health USA Inc.

USA Inc., Duluth, GA. US-PET-0039-2022.

References: 1. State of Pet Health

2016 Report. Banﬁeld

Pet Hospital. https://www.banﬁeld.com/

Banﬁeld/media/PDF/Downloads/soph/Banﬁeld-State-of-Pet-Health-Report-2016.pdf. Accessed

December 6, 2018. 2. AVMA. U.S. Pet Ownership Statistics. https://www.avma.org/KB/Resources/

Statistics/Pages/Market-research-statistics-US-pet-ownership.aspx. Accessed December 6, 2018.

3. Nelson RW, Henley K, Cole C, et al. Field safety and efﬁcacy of protamine zinc recombinant human

insulin for treatment of diabetes mellitus in cats. J Vet Intern Med. 2009;23:787–793. 4. PROZINC

(protamine zinc recombinant human insulin) [Freedom of Information Summary]. St. Joseph, MO:

Boehringer Ingelheim Vetmedica, Inc.; 2009. 5. Gostelow R, Forcada Y, Graves T, Church D, Niessen S.

Systematic review of feline diabetic remission: separating fact from opinion. Vet J. 2014;202(2):208–221.

18718

IF YOU HAVE QUESTIONS

REGARDING PROZINC

, PLEASE

CALL BOEHRINGER INGELHEIM

TECHNICAL SUPPORT AT

1-888-637-4251

No other information replaces the advice of your

veterinarian. Please don’t ever hesitate to contact your

veterinary professional with questions about your cat’s

diabetes or administering a PROZINC injection.